# LMO2

Source: https://onco.cc/targets/lmo2/  
OnCo record `lmo2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

LMO2 (Rhombotin-2) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Breast cancer.

## Summary

Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state.

Open Targets scores its association with cancer at 0.66 (direct and indirect evidence; datatypes affected pathway 0.35, literature 0.93, genetic association 0.03, somatic mutation 0.96, animal model 0.52).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: LIM domain only 2; Rhombotin-2; TTG2; RHOM2; RBTN2; RBTNL1
- Tags: cancer-genes-wave
- Symbol: LMO2
- Class: other
- Biology: Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state. Location: Nucleus (UniProt). Locus 11p13 (HGNC).
- Where found: Breast cancer: Open Targets association 0.51 with breast cancer (MONDO_0007254)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:6642: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6642
- UniProt P25791: https://www.uniprot.org/uniprotkb/P25791/entry
- NCBI Gene 4005: https://www.ncbi.nlm.nih.gov/gene/4005
- Ensembl ENSG00000135363: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000135363

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/)

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JSON: https://onco.cc/api/v1/entities/lmo2.json