# LMX1B

Source: https://onco.cc/targets/lmx1b/  
OnCo record `lmx1b` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

LMX1B (LIM homeobox transcription factor 1-beta) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Transcription factor involved in the regulation of podocyte-expressed genes. Essential for the specification of dorsal limb fate at both the zeugopodal and autopodal levels.

Open Targets scores its association with cancer at 0.50 (direct and indirect evidence; datatypes literature 0.80, animal model 0.69, genetic association 0.62).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: LIM homeobox transcription factor 1 beta; LIM homeobox transcription factor 1-beta; NPS1
- Tags: cancer-genes-wave
- Symbol: LMX1B
- Class: transcription
- Biology: Transcription factor involved in the regulation of podocyte-expressed genes. Essential for the specification of dorsal limb fate at both the zeugopodal and autopodal levels. Location: Nucleus (UniProt). Locus 9q33.3 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:6654: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6654
- UniProt O60663: https://www.uniprot.org/uniprotkb/O60663/entry
- NCBI Gene 4010: https://www.ncbi.nlm.nih.gov/gene/4010
- Ensembl ENSG00000136944: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000136944

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/lmx1b.json