# LPA

Source: https://onco.cc/targets/lpa/  
OnCo record `lpa` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

LPA (Apolipoprotein(a)) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Pancreatic ductal adenocarcinoma.

## Summary

Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1.

Open Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes literature 0.87, genetic association 0.63, somatic mutation 0.37). IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Pancreatic Adenocarcinoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: lipoprotein(a); Apolipoprotein(a); Lp(a)
- Tags: cancer-genes-wave
- Symbol: LPA
- Class: tumor-suppressor
- Biology: Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp(a) may be a ligand for megalin/Gp 330. Locus 6q25.3-q26 (HGNC).
- Where found: Pancreatic ductal adenocarcinoma: IntOGen driver in 1 cohort (PAAD)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:6667: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6667
- UniProt P08519: https://www.uniprot.org/uniprotkb/P08519/entry
- NCBI Gene 4018: https://www.ncbi.nlm.nih.gov/gene/4018
- Ensembl ENSG00000198670: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000198670

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Pancreatic ductal adenocarcinoma](https://onco.cc/cancers/pancreatic/)

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JSON: https://onco.cc/api/v1/entities/lpa.json