# LPP

Source: https://onco.cc/targets/lpp/  
OnCo record `lpp` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

LPP (Lipoma-preferred partner) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Skin cancer, Breast cancer, Non-Hodgkin lymphoma and 4 more.

## Summary

May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signalling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites.

Open Targets scores its association with cancer at 0.78 (direct and indirect evidence; datatypes literature 0.93, animal model 0.56, genetic association 0.79, somatic mutation 0.98).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: LIM domain containing preferred translocation partner in lipoma; Lipoma-preferred partner
- Tags: cancer-genes-wave
- Symbol: LPP
- Class: transcription
- Biology: May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signalling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus. Location: Nucleus; Cytoplasm; Cell junction; Cell membrane (UniProt). Locus 3q27.3-q28 (HGNC).
- Where found: Skin cancer: Open Targets association 0.63 with skin cancer (MONDO_0002898); Breast cancer: Open Targets association 0.57 with breast cancer (MONDO_0007254); Non-Hodgkin lymphoma: Open Targets association 0.52 with non-Hodgkin lymphoma (MONDO_0018908); Leukaemia: Open Targets association 0.51 with leukaemia (MONDO_0005059); Gastric & gastro-oesophageal junction cancer: Open Targets association 0.50 with gastric cancer (MONDO_0001056); Neuroendocrine tumours: Open Targets association 0.50 with neuroendocrine neoplasm (MONDO_0019496)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:6679: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6679
- UniProt Q93052: https://www.uniprot.org/uniprotkb/Q93052/entry
- NCBI Gene 4026: https://www.ncbi.nlm.nih.gov/gene/4026
- Ensembl ENSG00000145012: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000145012

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Basal cell carcinoma](https://onco.cc/cancers/basal-cell-carcinoma/), [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/), [Gastric & gastro-oesophageal junction cancer](https://onco.cc/cancers/gastric/), [Leukaemia (all types)](https://onco.cc/cancers/leukaemia/), [Neuroendocrine tumours](https://onco.cc/cancers/neuroendocrine/), [Non-Hodgkin lymphoma (all types)](https://onco.cc/cancers/non-hodgkin-lymphoma/), [Skin cancer (all types)](https://onco.cc/cancers/skin-cancer/)

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JSON: https://onco.cc/api/v1/entities/lpp.json