# LRFN2

Source: https://onco.cc/targets/lrfn2/  
OnCo record `lrfn2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

LRFN2 (Leucine-rich repeat and fibronectin type-III domain-containing protein 2) is a gene. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Promotes neurite outgrowth in hippocampal neurons. Enhances the cell surface expression of 2 NMDA receptor subunits GRIN1 and GRIN2A. May play a role in redistributing DLG4 to the cell periphery.

Open Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.81, animal model 0.55, genetic association 0.65).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: leucine rich repeat and fibronectin type III domain containing 2; Leucine-rich repeat and fibronectin type-III domain-containing protein 2; FIGLER2; KIAA1246; SALM1
- Tags: cancer-genes-wave
- Symbol: LRFN2
- Class: other
- Biology: Promotes neurite outgrowth in hippocampal neurons. Enhances the cell surface expression of 2 NMDA receptor subunits GRIN1 and GRIN2A. May play a role in redistributing DLG4 to the cell periphery. Location: Membrane; Synapse; Postsynaptic cell membrane (UniProt). Locus 6p21.2-p21.1 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:21226: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:21226
- UniProt Q9ULH4: https://www.uniprot.org/uniprotkb/Q9ULH4/entry
- NCBI Gene 57497: https://www.ncbi.nlm.nih.gov/gene/57497
- Ensembl ENSG00000156564: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000156564

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/lrfn2.json