# LRRFIP1

Source: https://onco.cc/targets/lrrfip1/  
OnCo record `lrrfip1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

LRRFIP1 (Leucine-rich repeat flightless-interacting protein 1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Leukaemia.

## Summary

Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA.

Open Targets scores its association with cancer at 0.65 (direct and indirect evidence; datatypes literature 0.83, affected pathway 0.94, genetic association 0.37).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: LRR binding FLII interacting protein 1; Leucine-rich repeat flightless-interacting protein 1; FLAP-1; FLIIAP1; GCF-2; HUFI-1; GCF2
- Tags: cancer-genes-wave
- Symbol: LRRFIP1
- Class: transcription
- Biology: Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signalling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. Location: Nucleus; Cytoplasm (UniProt). Locus 2q37.3 (HGNC).
- Where found: Leukaemia: Open Targets association 0.51 with leukaemia (MONDO_0005059)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:6702: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6702
- UniProt Q32MZ4: https://www.uniprot.org/uniprotkb/Q32MZ4/entry
- NCBI Gene 9208: https://www.ncbi.nlm.nih.gov/gene/9208
- Ensembl ENSG00000124831: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000124831

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Leukaemia (all types)](https://onco.cc/cancers/leukaemia/)

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JSON: https://onco.cc/api/v1/entities/lrrfip1.json