# LSM14A

Source: https://onco.cc/targets/lsm14a/  
OnCo record `lsm14a` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

LSM14A (Protein LSM14 homolog A) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Endometrial cancer.

## Summary

Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for translationally inactive mRNAs and protect them from degradation. Acts as a repressor of mRNA translation. May play a role in mitotic spindle assembly.

IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Endometrial Carcinoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: LSM14A mRNA processing body assembly factor; Protein LSM14 homolog A; DKFZP434D1335; RAP55A; RAP55; C19orf13; FAM61A
- Tags: cancer-genes-wave
- Symbol: LSM14A
- Class: oncogene
- Biology: Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for translationally inactive mRNAs and protect them from degradation. Acts as a repressor of mRNA translation. May play a role in mitotic spindle assembly. Location: Cytoplasm, P-body; Cytoplasm, cytoskeleton, spindle; Cytoplasm, Stress granule (UniProt). Locus 19q13.11 (HGNC).
- Where found: Endometrial cancer: IntOGen driver in 1 cohort (UCEC)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:24489: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:24489
- UniProt Q8ND56: https://www.uniprot.org/uniprotkb/Q8ND56/entry
- NCBI Gene 26065: https://www.ncbi.nlm.nih.gov/gene/26065
- Ensembl ENSG00000257103: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000257103

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Endometrial cancer](https://onco.cc/cancers/endometrial/)

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JSON: https://onco.cc/api/v1/entities/lsm14a.json