# LSP1

Source: https://onco.cc/targets/lsp1/  
OnCo record `lsp1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

LSP1 (Lymphocyte-specific protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer.

## Summary

May play a role in mediating neutrophil activation and chemotaxis.

Open Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.95, genetic association 0.66).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: lymphocyte specific protein 1; Lymphocyte-specific protein 1; WP34
- Tags: cancer-genes-wave
- Symbol: LSP1
- Class: other
- Biology: May play a role in mediating neutrophil activation and chemotaxis. Location: Cell membrane (UniProt). Locus 11p15.5 (HGNC).
- Where found: Breast cancer: Open Targets association 0.50 with breast cancer (MONDO_0007254)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:6707: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6707
- UniProt P33241: https://www.uniprot.org/uniprotkb/P33241/entry
- NCBI Gene 4046: https://www.ncbi.nlm.nih.gov/gene/4046
- Ensembl ENSG00000130592: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000130592

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/)

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JSON: https://onco.cc/api/v1/entities/lsp1.json