# LTB

Source: https://onco.cc/targets/ltb/  
OnCo record `ltb` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

LTB (Lymphotoxin-beta) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.

## Summary

Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: lymphotoxin beta; Lymphotoxin-beta; p33; TNFSF3
- Tags: cancer-genes-wave
- Symbol: LTB
- Class: other
- Biology: Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional. Location: Membrane (UniProt). Locus 6p21.33 (HGNC).
- Where found: Diffuse large B-cell lymphoma: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:6711: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6711
- UniProt Q06643: https://www.uniprot.org/uniprotkb/Q06643/entry
- NCBI Gene 4050: https://www.ncbi.nlm.nih.gov/gene/4050
- Ensembl ENSG00000227507: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000227507

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Diffuse large B-cell lymphoma](https://onco.cc/cancers/dlbcl/)

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JSON: https://onco.cc/api/v1/entities/ltb.json