# LYL1

Source: https://onco.cc/targets/lyl1/  
OnCo record `lyl1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

LYL1 (LYL1 basic helix-loop-helix family member) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.

## Summary

Transcriptional coactivator that interacts with CREB1 and activates several CREB1-responsive genes.

Open Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.76, animal model 0.49, genetic association 0.15, somatic mutation 0.94).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: LYL1 basic helix-loop-helix family member; bHLHa18
- Tags: cancer-genes-wave
- Symbol: LYL1
- Class: transcription
- Biology: Transcriptional coactivator that interacts with CREB1 and activates several CREB1-responsive genes. Location: Nucleus (UniProt). Locus 19p13.13 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:6734: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6734
- UniProt P12980: https://www.uniprot.org/uniprotkb/P12980/entry
- NCBI Gene 4066: https://www.ncbi.nlm.nih.gov/gene/4066
- Ensembl ENSG00000104903: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000104903

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/lyl1.json