# Prognostic Index for T-cell lymphoma (PIT)

Source: https://onco.cc/terms/lymphoma-pit-score/  
OnCo record `lymphoma-pit-score` (Term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A four-item score that estimates the outlook in nodal T-cell lymphoma, built because the index used for B-cell lymphoma separated these patients poorly. It counts age over 60, a performance status of 2 or worse, a raised lactate dehydrogenase, and lymphoma in the bone marrow.

## Summary

The Prognostic Index for T-cell lymphoma was built from 385 patients with peripheral T-cell lymphoma unspecified, classified by the WHO criteria and analysed retrospectively across several Italian centres (Gallamini, Blood 2004). Four features were independently predictive of survival: age over 60 years, a performance status of 2 or worse, a lactate dehydrogenase above the normal range, and bone marrow involvement.

The four groups it defines had five-year overall survival of 62.3 per cent with no adverse factor, 52.9 per cent with one, and lower with two or more; ten-year survival in the two best groups was 54.9 and 38.8 per cent. Those figures come from patients treated before brentuximab vedotin and before routine transplant consolidation, and they describe a population rather than a person.

It is used alongside, not instead of, the International Prognostic Index, and it does not change which treatment is given: there is no randomised evidence that a higher score should lead to a different regimen. Its honest use is to set expectations and to stratify trials. A separate index, PINK, exists for extranodal NK/T-cell lymphoma and is described on that page.

## Fields

- Kind: Term
- Last checked: 2026-09-29
- Also known as: PIT; PIT score; Prognostic Index for PTCL-U; prognostic index for peripheral T-cell lymphoma
- Tags: heme; lymphoma

## Sources

- Peripheral T-cell lymphoma unspecified: the Prognostic Index for T-cell lymphoma (Gallamini, Blood 2004): https://doi.org/10.1182/blood-2003-09-3080
- A predictive model for aggressive non-Hodgkin's lymphoma: the International Prognostic Index (N Engl J Med 1993): https://doi.org/10.1056/NEJM199309303291402

## Connected records

- terms: [FLIPI, FLIPI2 and POD24 (follicular lymphoma risk)](https://onco.cc/terms/flipi/), [International Prognostic Index (IPI)](https://onco.cc/terms/ipi-score/), [MIPI (Mantle Cell Lymphoma International Prognostic Index)](https://onco.cc/terms/mipi/)
- cancers: [Adult T-cell leukaemia/lymphoma](https://onco.cc/cancers/adult-t-cell-leukaemia-lymphoma/), [ALK-negative anaplastic large cell lymphoma](https://onco.cc/cancers/alk-negative-anaplastic-large-cell-lymphoma/), [ALK-positive anaplastic large cell lymphoma](https://onco.cc/cancers/alk-positive-anaplastic-large-cell-lymphoma/), [Enteropathy-associated T-cell lymphoma](https://onco.cc/cancers/enteropathy-associated-t-cell-lymphoma/), [Extranodal NK/T-cell lymphoma](https://onco.cc/cancers/extranodal-nk-t-cell-lymphoma/), [Monomorphic epitheliotropic intestinal T-cell lymphoma](https://onco.cc/cancers/monomorphic-epitheliotropic-intestinal-t-cell-lymphoma/), [Nodal T-follicular helper cell lymphoma, angioimmunoblastic type (angioimmunoblastic T-cell lymphoma)](https://onco.cc/cancers/angioimmunoblastic-t-cell-lymphoma/), [Non-Hodgkin lymphoma (all types)](https://onco.cc/cancers/non-hodgkin-lymphoma/), [Peripheral T-cell lymphomas (including cutaneous T-cell lymphoma)](https://onco.cc/cancers/peripheral-t-cell-lymphoma/)

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