# LYN kinase

Source: https://onco.cc/targets/lyn/  
OnCo record `lyn` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

LYN is a SRC-family kinase that sits under the B-cell receptor; dasatinib and bosutinib inhibit it alongside BCR-ABL, and LYN over-activity is one way chronic myeloid leukaemia escapes imatinib.

## Summary

LYN is a SRC-family tyrosine kinase expressed in B cells and myeloid cells, where it both amplifies and restrains signalling from the B-cell receptor and cytokine receptors. In chronic myeloid leukaemia, over-expression of LYN is a recognised mechanism of imatinib resistance that does not involve a BCR-ABL mutation, and the second-generation inhibitors dasatinib and bosutinib block LYN and other SRC kinases directly. LYN is also constitutively active in chronic lymphocytic leukaemia cells, contributing to their survival.

## Fields

- Kind: Target
- Last checked: 2026-09-04
- Tags: chembl-gap
- Symbol: LYN
- Class: kinase
- Biology: A membrane-anchored non-receptor tyrosine kinase; it phosphorylates immunoreceptor tyrosine motifs to start SYK signalling and also activates inhibitory phosphatases, giving it dual roles.
- Where found: B lymphocytes and myeloid cells; Imatinib-resistant CML and CLL cells

## Sources

- Wikipedia: https://en.wikipedia.org/wiki/LYN_(gene)
- UniProt P07948: LYN: https://www.uniprot.org/uniprotkb/P07948/entry
- HGNC:6735 LYN: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6735
- ChEMBL target CHEMBL3905: https://www.ebi.ac.uk/chembl/explore/target/CHEMBL3905

## Connected records

- targets: [BCR::ABL1 (Philadelphia chromosome)](https://onco.cc/targets/bcr-abl/), [HCK kinase](https://onco.cc/targets/hck/), [SRC family kinases](https://onco.cc/targets/src/)
- cancers: [Acute myeloid leukaemia](https://onco.cc/cancers/aml/), [Chronic lymphocytic leukaemia](https://onco.cc/cancers/cll/), [Chronic myeloid leukaemia (CML)](https://onco.cc/cancers/cml/)
- drugs: [Bosutinib](https://onco.cc/drugs/bosutinib/), [Dasatinib](https://onco.cc/drugs/dasatinib/)

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JSON: https://onco.cc/api/v1/entities/lyn.json