# LYRIC (lymphoma response to immunomodulatory therapy criteria)

Source: https://onco.cc/terms/lyric/  
OnCo record `lyric` (Term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

LYRIC adds an 'indeterminate response' to the lymphoma response rules for immunotherapy, so that apparent growth from a flare is not mistaken for failure before a biopsy or later scan settles it.

## Summary

Checkpoint inhibitors and other immunomodulatory drugs can cause tumour flare or pseudoprogression in lymphoma, and calling that progressive disease could take patients off a treatment that is working. A workshop (Cheson and colleagues, Blood 2016) gave provisional recommendations modifying the Lugano criteria for these drugs in trials, introducing indeterminate response for such lesions until biopsy or later imaging confirms flare or true progression.

## Fields

- Kind: Term
- Last checked: 2026-11-04
- Also known as: LYRIC; LYRIC criteria; indeterminate response

## Sources

- Cheson et al., Refinement of the Lugano Classification lymphoma response criteria in the era of immunomodulatory therapy (Blood 2016): https://doi.org/10.1182/blood-2016-05-718528

## Connected records

- terms: [Complete response (CR) and partial response (PR)](https://onco.cc/terms/complete-response-term/), [iRECIST (response criteria for immunotherapy trials)](https://onco.cc/terms/irecist/), [Lugano classification / Ann Arbor staging](https://onco.cc/terms/lugano-classification/), [Progressive disease and radiographic progression](https://onco.cc/terms/progressive-disease/), [Revised response criteria for malignant lymphoma (Cheson 2007)](https://onco.cc/terms/cheson-2007/)
- cancers: [Hodgkin lymphoma](https://onco.cc/cancers/hodgkin-lymphoma/), [Non-Hodgkin lymphoma (all types)](https://onco.cc/cancers/non-hodgkin-lymphoma/)
- technologies: [FDG PET](https://onco.cc/technologies/fdg-pet/), [Immune checkpoint inhibitors](https://onco.cc/technologies/checkpoint-inhibitor/)

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