# MACC1

Source: https://onco.cc/targets/macc1/  
OnCo record `macc1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

MACC1 (Metastasis-associated in colon cancer protein 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Non-small-cell lung cancer.

## Summary

Acts as a transcription activator for MET and as a key regulator of HGF-MET signalling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumour growth and metastasis in vivo.

IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Lung Adenocarcinoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: MET transcriptional regulator MACC1; Metastasis-associated in colon cancer protein 1; 7A5; SH3BP4L
- Tags: cancer-genes-wave
- Symbol: MACC1
- Class: tumor-suppressor
- Biology: Acts as a transcription activator for MET and as a key regulator of HGF-MET signalling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumour growth and metastasis in vivo. Location: Cytoplasm; Nucleus (UniProt). Locus 7p21.1 (HGNC).
- Where found: Non-small-cell lung cancer: IntOGen driver in 1 cohort (LUAD)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:30215: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:30215
- UniProt Q6ZN28: https://www.uniprot.org/uniprotkb/Q6ZN28/entry
- NCBI Gene 346389: https://www.ncbi.nlm.nih.gov/gene/346389
- Ensembl ENSG00000183742: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000183742

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/)

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JSON: https://onco.cc/api/v1/entities/macc1.json