# Magnetic nanoparticle hyperthermia

Source: https://onco.cc/technologies/magnetic-nanoparticle-hyperthermia/  
OnCo record `magnetic-nanoparticle-hyperthermia` (Technology). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Magnetic nanoparticle hyperthermia injects iron-oxide nanoparticles into a tumour and heats them from outside with an alternating magnetic field.

## Summary

NanoTherm received European approval for glioblastoma in 2010 and is used at a small number of German centres, usually with radiotherapy. A phase 2 adjuvant glioblastoma study is recruiting in Poland (NCT06271421); the US prostate focal-ablation study (NCT05010759) was terminated. Systemically delivered magnetic hyperthermia, as opposed to direct intratumoural injection, is still preclinical.

## Fields

- Kind: Technology
- Status: phase-2
- Last checked: 2026-09-08
- Tags: frontier
- Principle: Superparamagnetic iron-oxide nanoparticles deposited in the tumour dissipate heat under an alternating magnetic field, reaching 40-45 °C and sensitising cells to radiation and chemotherapy.
- Strengths: Heat is generated only where particles sit; Adds to radiotherapy without extra systemic toxicity; Approved precedent in Europe
- Limitations: Requires direct injection and a specialised field applicator; Uneven particle distribution gives uneven heating; Very few centres; a troubled commercial history

## Sources

- NanoTherm adjuvant GBM phase 2 (NCT06271421): https://clinicaltrials.gov/study/NCT06271421

## Connected records

- cancers: [Glioma & glioblastoma](https://onco.cc/cancers/glioblastoma/), [Prostate cancer](https://onco.cc/cancers/prostate/)
- fronts: [Devices & Physical Therapies](https://onco.cc/fronts/devices/), [Radiation Therapy](https://onco.cc/fronts/radiation/)
- technologies: [Hyperthermia](https://onco.cc/technologies/hyperthermia/), [Hyperthermia systems (BSD-2000, EHY-2000, superficial and interstitial applicators)](https://onco.cc/technologies/hyperthermia-systems/), [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/), [Thermal ablation (RFA, microwave, cryo)](https://onco.cc/technologies/thermal-ablation/)
- journals: [International journal of hyperthermia](https://onco.cc/journals/international-journal-of-hyperthermia/)
- roadmaps: [Devices and physical therapies roadmap: heat and light → electric fields and focused sound → drug-releasing implants](https://onco.cc/roadmaps/devices-roadmap/), [Radical oncology: what could change the war by 2035](https://onco.cc/roadmaps/frontier-2035/)

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