# Mahesh K. B. Parmar

Source: https://onco.cc/people/mahesh-parmar/  
OnCo record `mahesh-parmar` (Person). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Statistician who invented the multi-arm multi-stage design behind STAMPEDE, letting one trial test many treatments at once.

## Summary

Mahesh Parmar developed the multi-arm multi-stage (MAMS) platform trial design and applied it in STAMPEDE, which tested ten treatment approaches for advanced prostate cancer in a single trial and established docetaxel and abiraterone as standards. He directs the MRC Clinical Trials Unit at UCL, which runs trials across cancer, HIV and tuberculosis, and has led methodological work on adaptive designs and meta-analysis.

## Fields

- Kind: Person
- Last checked: 2026-09-10
- Tags: biostatistics; trial-design; platform-trials
- Role: Director, MRC Clinical Trials Unit at UCL; Professor of Medical Statistics and Epidemiology
- Specialisms: Multi-arm multi-stage trial design; Prostate cancer trials; Biostatistics; Trial methodology

## Sources

- PubMed: https://pubmed.ncbi.nlm.nih.gov/?term=Parmar%20MKB%5BAuthor%5D%20multi-arm%20multi-stage

## Connected records

- cancers: [Prostate cancer](https://onco.cc/cancers/prostate/)
- institutions: [University College London Hospitals / UCL Cancer Institute](https://onco.cc/institutions/uclh/)
- trials: [STAMPEDE](https://onco.cc/trials/stampede/)
- key papers: [STAMPEDE: adding abiraterone to hormone therapy at diagnosis of advanced prostate cancer](https://onco.cc/key-papers/paper-stampede-abiraterone-nejm-2017/)
- terms: [Master protocol (platform, basket and umbrella trials)](https://onco.cc/terms/master-protocol/)

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