# MAML1

Source: https://onco.cc/targets/maml1/  
OnCo record `maml1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

MAML1 (Mastermind-like protein 1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8.

Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.88, affected pathway 0.94, genetic association 0.00, somatic mutation 0.23).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: mastermind like transcriptional coactivator 1; Mastermind-like protein 1; KIAA0200; Mam-1
- Tags: cancer-genes-wave
- Symbol: MAML1
- Class: transcription
- Biology: Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localisation of CREBBP to nuclear foci. Plays a role in haematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. Location: Nucleus speckle (UniProt). Locus 5q35.3 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:13632: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13632
- UniProt Q92585: https://www.uniprot.org/uniprotkb/Q92585/entry
- NCBI Gene 9794: https://www.ncbi.nlm.nih.gov/gene/9794
- Ensembl ENSG00000161021: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000161021

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/maml1.json