# MAML3

Source: https://onco.cc/targets/maml3/  
OnCo record `maml3` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

MAML3 (Mastermind-like protein 3) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1.

Open Targets scores its association with cancer at 0.68 (direct and indirect evidence; datatypes literature 0.30, affected pathway 0.94, genetic association 0.56).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: mastermind like transcriptional coactivator 3; Mastermind-like protein 3; KIAA1816; MAM2; CAGH3; TNRC3
- Tags: cancer-genes-wave
- Symbol: MAML3
- Class: transcription
- Biology: Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Location: Nucleus speckle (UniProt). Locus 4q31.1 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:16272: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:16272
- UniProt Q96JK9: https://www.uniprot.org/uniprotkb/Q96JK9/entry
- NCBI Gene 55534: https://www.ncbi.nlm.nih.gov/gene/55534
- Ensembl ENSG00000196782: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000196782

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/maml3.json