# MAMLD1

Source: https://onco.cc/targets/mamld1/  
OnCo record `mamld1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

MAMLD1 (Mastermind-like domain-containing protein 1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Transactivates the HES3 promoter independently of NOTCH proteins. HES3 is a non-canonical NOTCH target gene which lacks binding sites for RBPJ.

Open Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes affected pathway 0.94, literature 0.12, genetic association 0.00, somatic mutation 0.23, animal model 0.35).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: mastermind like domain containing 1; Mastermind-like domain-containing protein 1; CG1; F18; CXorf6
- Tags: cancer-genes-wave
- Symbol: MAMLD1
- Class: transcription
- Biology: Transactivates the HES3 promoter independently of NOTCH proteins. HES3 is a non-canonical NOTCH target gene which lacks binding sites for RBPJ. Location: Nucleus (UniProt). Locus Xq28 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:2568: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2568
- UniProt Q13495: https://www.uniprot.org/uniprotkb/Q13495/entry
- NCBI Gene 10046: https://www.ncbi.nlm.nih.gov/gene/10046
- Ensembl ENSG00000013619: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000013619

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/mamld1.json