# MAP3K13

Source: https://onco.cc/targets/map3k13/  
OnCo record `map3k13` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

MAP3K13 (Mitogen-activated protein kinase kinase kinase 13) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer, Breast cancer, Lung cancer and 1 more.

## Summary

Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B.

Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.87, genetic association 0.00, somatic mutation 0.98).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: mitogen-activated protein kinase kinase kinase 13; Mitogen-activated protein kinase kinase kinase 13; MEKK13
- Tags: cancer-genes-wave
- Symbol: MAP3K13
- Class: kinase
- Biology: Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B. Location: Cytoplasm; Membrane (UniProt). Locus 3q27.2 (HGNC).
- Where found: Skin cancer: Open Targets association 0.55 with skin cancer (MONDO_0002898); Breast cancer: Open Targets association 0.53 with breast cancer (MONDO_0007254); Lung cancer: Open Targets association 0.51 with lung cancer (MONDO_0008903); Melanoma: Open Targets association 0.55 with melanoma (MONDO_0005105)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:6852: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6852
- UniProt O43283: https://www.uniprot.org/uniprotkb/O43283/entry
- NCBI Gene 9175: https://www.ncbi.nlm.nih.gov/gene/9175
- Ensembl ENSG00000073803: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000073803

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/), [Lung cancer (all types)](https://onco.cc/cancers/lung-cancer/), [Melanoma](https://onco.cc/cancers/melanoma/), [Skin cancer (all types)](https://onco.cc/cancers/skin-cancer/)

---
JSON: https://onco.cc/api/v1/entities/map3k13.json