# Marc G. Besselink

Source: https://onco.cc/people/marc-besselink/  
OnCo record `marc-besselink` (Person). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Dutch surgeon who leads the PREOPANC trials testing chemotherapy or chemoradiation before pancreatic cancer surgery.

## Summary

Marc Besselink (Amsterdam UMC) leads the Dutch Pancreatic Cancer Group and was senior investigator of PREOPANC, the randomised trial showing neoadjuvant chemoradiotherapy improves long-term survival in resectable and borderline resectable pancreatic cancer, and of PREOPANC-2 comparing neoadjuvant FOLFIRINOX. He has led the DIPLOMA and LEOPARD trials of minimally invasive pancreatic surgery.

## Fields

- Kind: Person
- Last checked: 2026-09-10
- Tags: pancreatic; surgery; neoadjuvant
- Role: Professor of Pancreatic and Hepatobiliary Surgery, Amsterdam UMC
- Specialisms: Pancreatic surgery; Neoadjuvant therapy; Minimally invasive pancreatectomy; Surgical trials

## Sources

- PubMed: https://pubmed.ncbi.nlm.nih.gov/?term=Besselink%20MG%5BAuthor%5D%20pancreatic%20PREOPANC

## Connected records

- cancers: [Borderline resectable pancreatic ductal adenocarcinoma](https://onco.cc/cancers/borderline-resectable-pdac/), [Intraductal papillary mucinous neoplasm and other pancreatic cystic precursors](https://onco.cc/cancers/ipmn-cystic-precursors/), [Pancreatic ductal adenocarcinoma](https://onco.cc/cancers/pancreatic/), [Resectable pancreatic ductal adenocarcinoma](https://onco.cc/cancers/resectable-pdac/)
- technologies: [Robotic & minimally invasive surgery](https://onco.cc/technologies/robotic-surgery/)
- institutions: [Amsterdam UMC / Cancer Center Amsterdam](https://onco.cc/institutions/amsterdam-umc/)
- trials: [PREOPANC-1](https://onco.cc/trials/preopanc/), [PREOPANC-2](https://onco.cc/trials/preopanc-2/)
- key papers: [Neoadjuvant FOLFIRINOX versus neoadjuvant gemcitabine-based chemoradiotherapy in resectable and borderline resectable pancreatic cancer (PREOPANC-2): a multicentre, open-label, phase 3 randomised trial](https://onco.cc/key-papers/paper-preopanc-2-neoadjuvant-folfirinox-vs-chemoradiotherapy-lancet-oncol-2025/), [Preoperative Chemoradiotherapy Versus Immediate Surgery for Resectable and Borderline Resectable Pancreatic Cancer: Results of the Dutch Randomized Phase III PREOPANC Trial](https://onco.cc/key-papers/paper-preopanc-preoperative-chemoradiotherapy-jco-2020/)
- roadmaps: [Pancreatic cancer roadmap: from Whipple's operation to gemcitabine, FOLFIRINOX, adjuvant chemotherapy, PARP inhibition, KRAS inhibition, vaccines and the surveillance question](https://onco.cc/roadmaps/pancreatic-roadmap/)

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