# Marcela V. Maus

Source: https://onco.cc/people/marcela-maus/  
OnCo record `marcela-maus` (Person). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Cell therapy engineer whose CAR-TEAM cells produced rapid regressions of recurrent glioblastoma.

## Summary

Marcela Maus leads a laboratory that engineers CAR T cells to overcome the barriers of solid tumours, including the CARv3-TEAM-E cells that secrete a T-cell-engaging antibody against EGFR and produced dramatic, if transient, radiographic regressions in recurrent glioblastoma in a 2024 first-in-human trial. She previously led the first EGFRvIII CAR-T trial at Penn and directs cellular immunotherapy at MGH.

## Fields

- Kind: Person
- Last checked: 2026-09-10
- Tags: cell-therapy; car-t; solid-tumours
- Role: Director, Cellular Immunotherapy Program, Massachusetts General Hospital Cancer Center; Professor, Harvard Medical School
- Specialisms: CAR T-cell therapy; Solid tumour cell therapy; Glioblastoma; CAR engineering

## Sources

- PubMed: https://pubmed.ncbi.nlm.nih.gov/?term=Maus%20MV%5BAuthor%5D%20CAR%20T%20glioblastoma

## Connected records

- cancers: [Glioma & glioblastoma](https://onco.cc/cancers/glioblastoma/)
- technologies: [Armoured, logic-gated & next-gen CARs](https://onco.cc/technologies/armored-car/), [CAR-T cell therapy](https://onco.cc/technologies/car-t/)
- targets: [EGFR](https://onco.cc/targets/egfr/)
- institutions: [Massachusetts General Hospital Cancer Center](https://onco.cc/institutions/mgh/)
- journals: [Science Translational Medicine](https://onco.cc/journals/science-translational-medicine/)

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JSON: https://onco.cc/api/v1/entities/marcela-maus.json