# MARK2

Source: https://onco.cc/targets/mark2/  
OnCo record `mark2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

MARK2 (Serine/threonine-protein kinase MARK2) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Pancreatic ductal adenocarcinoma.

## Summary

Serine/threonine-protein kinase. Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2.

IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Pancreatic Adenocarcinoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: microtubule affinity regulating kinase 2; Serine/threonine-protein kinase MARK2; PAR-1; Par1b; PAR-1B; EMK1
- Tags: cancer-genes-wave
- Symbol: MARK2
- Class: kinase
- Biology: Serine/threonine-protein kinase. Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU. Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Location: Cell membrane; Cytoplasm; Lateral cell membrane; Cytoplasm, cytoskeleton (UniProt). Locus 11q13.1 (HGNC).
- Where found: Pancreatic ductal adenocarcinoma: IntOGen driver in 1 cohort (PAAD)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:3332: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3332
- UniProt Q7KZI7: https://www.uniprot.org/uniprotkb/Q7KZI7/entry
- NCBI Gene 2011: https://www.ncbi.nlm.nih.gov/gene/2011
- Ensembl ENSG00000072518: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000072518

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Pancreatic ductal adenocarcinoma](https://onco.cc/cancers/pancreatic/)

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JSON: https://onco.cc/api/v1/entities/mark2.json