# MARK3

Source: https://onco.cc/targets/mark3/  
OnCo record `mark3` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

MARK3 (MAP/microtubule affinity-regulating kinase 3) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Serine/threonine-protein kinase. Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU.

Open Targets scores its association with cancer at 0.64 (direct and indirect evidence; datatypes literature 0.80, affected pathway 0.97, genetic association 0.22).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: microtubule affinity regulating kinase 3; MAP/microtubule affinity-regulating kinase 3; CTAK1; KP78; PAR-1A
- Tags: cancer-genes-wave
- Symbol: MARK3
- Class: kinase
- Biology: Serine/threonine-protein kinase. Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU. Phosphorylates CDC25C on 'Ser-216'. Regulates localisation and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Regulates localisation and activity of MITF by mediating its phosphorylation, promoting subsequent interaction between MITF and 14-3-3 and retention in the cytosol. Location: Cell membrane; Cell projection, dendrite; Cytoplasm (UniProt). Locus 14q32.32-q32.33 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:6897: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6897
- UniProt P27448: https://www.uniprot.org/uniprotkb/P27448/entry
- NCBI Gene 4140: https://www.ncbi.nlm.nih.gov/gene/4140
- Ensembl ENSG00000075413: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000075413

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/mark3.json