# MB21D2

Source: https://onco.cc/targets/mb21d2/  
OnCo record `mb21d2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

MB21D2 (Nucleotidyltransferase MB21D2) is an enzyme. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Head and neck squamous cell carcinoma, Sarcomas, Bladder & urothelial cancer and 2 more.

## Summary

Probable nucleotidyltransferase that catalyses the formation of cyclic dinucleotide second messenger in response to some unknown stimulus.

IntOGen calls it a driver in 4 cohorts (1 activating, 3 loss-of-function), covering Head and Neck Squamous Cell Carcinoma, Liposarcoma, Lung Squamous Cell Carcinoma, Upper Tract Urothelial Carcinoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: Mab-21 domain containing 2; Nucleotidyltransferase MB21D2; D2A; C3orf59
- Tags: cancer-genes-wave
- Symbol: MB21D2
- Class: enzyme
- Biology: Probable nucleotidyltransferase that catalyses the formation of cyclic dinucleotide second messenger in response to some unknown stimulus. Locus 3q29 (HGNC).
- Where found: Head and neck squamous cell carcinoma: IntOGen driver in 1 cohort (HNSC); Sarcomas: IntOGen driver in 1 cohort (LIPO); Bladder & urothelial cancer: IntOGen driver in 1 cohort (UTUC); Liposarcoma: IntOGen driver in 1 cohort (LIPO); Non-small-cell lung cancer: IntOGen driver in 1 cohort (LUSC)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; IntOGen calls it a loss-of-function (LoF) driver in 3 cohorts. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:30438: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:30438
- UniProt Q8IYB1: https://www.uniprot.org/uniprotkb/Q8IYB1/entry
- NCBI Gene 151963: https://www.ncbi.nlm.nih.gov/gene/151963
- Ensembl ENSG00000180611: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000180611

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Bladder & urothelial cancer](https://onco.cc/cancers/urothelial/), [Head and neck squamous cell carcinoma](https://onco.cc/cancers/head-and-neck/), [Liposarcoma](https://onco.cc/cancers/liposarcoma/), [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/), [Sarcomas (soft tissue, bone, GIST)](https://onco.cc/cancers/sarcoma/)

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JSON: https://onco.cc/api/v1/entities/mb21d2.json