# MCM7

Source: https://onco.cc/targets/mcm7/  
OnCo record `mcm7` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

MCM7 (DNA replication licensing factor MCM7) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Cervical cancer.

## Summary

Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit.

IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Cervical Squamous Cell Carcinoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: minichromosome maintenance complex component 7; DNA replication licensing factor MCM7; CDC47; PPP1R104; MCM2
- Tags: cancer-genes-wave
- Symbol: MCM7
- Class: tumor-suppressor
- Biology: Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for S-phase checkpoint activation upon UV-induced damage. Location: Nucleus; Chromosome (UniProt). Locus 7q22.1 (HGNC).
- Where found: Cervical cancer: IntOGen driver in 1 cohort (CESC)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:6950: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6950
- UniProt P33993: https://www.uniprot.org/uniprotkb/P33993/entry
- NCBI Gene 4176: https://www.ncbi.nlm.nih.gov/gene/4176
- Ensembl ENSG00000166508: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000166508

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Cervical cancer](https://onco.cc/cancers/cervical/)

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JSON: https://onco.cc/api/v1/entities/mcm7.json