# MDGA2

Source: https://onco.cc/targets/mdga2/  
OnCo record `mdga2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

MDGA2 (MAM domain-containing glycosylphosphatidylinositol anchor protein 2) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Melanoma.

## Summary

May be involved in cell-cell interactions.

IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Melanoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: MAM domain containing glycosylphosphatidylinositol anchor 2; MAM domain-containing glycosylphosphatidylinositol anchor protein 2; MAMDC1
- Tags: cancer-genes-wave
- Symbol: MDGA2
- Class: oncogene
- Biology: May be involved in cell-cell interactions. Location: Cell membrane (UniProt). Locus 14q21.3 (HGNC).
- Where found: Melanoma: IntOGen driver in 1 cohort (MEL)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:19835: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:19835
- UniProt Q7Z553: https://www.uniprot.org/uniprotkb/Q7Z553/entry
- NCBI Gene 161357: https://www.ncbi.nlm.nih.gov/gene/161357
- Ensembl ENSG00000139915: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000139915

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Melanoma](https://onco.cc/cancers/melanoma/)

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JSON: https://onco.cc/api/v1/entities/mdga2.json