# c-Met protein overexpression (IHC 3+ in >= 50% of tumour cells)

Source: https://onco.cc/biomarkers/met-overexpression/  
OnCo record `met-overexpression` (Biomarker). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

c-Met overexpression is a stain, not a gene change: strong (3+) membrane staining in at least half of tumour cells. It selects telisotuzumab vedotin, an antibody-drug conjugate, in previously treated non-squamous lung cancer.

## Summary

The VENTANA MET (SP44) RxDx Assay scores c-Met protein on tumour cell membranes and cytoplasm; the telisotuzumab vedotin (Emrelis, May 2025) label defines high c-Met overexpression as 50 percent or more of tumour cells with strong (3+) staining, as determined by an FDA-approved test, in locally advanced or metastatic non-squamous NSCLC after prior systemic therapy (LUMINOSITY). About a quarter of non-squamous, EGFR wild-type lung cancers meet the bar. Overexpression can occur without amplification or exon 14 skipping and the three readouts are scored separately.

## Fields

- Kind: Biomarker
- Last checked: 2026-09-23
- Also known as: c-Met overexpression; MET overexpression; c-Met high; MET IHC 3+; c-Met protein overexpression; MET SP44; c-Met-high NSCLC
- Tags: biomarker; met

## Sources

- EMRELIS prescribing information (DailyMed): https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=bc04f980-3957-4e35-ab81-8ec2ffe87215

## Connected records

- biomarkers: [MET amplification (gene copy number)](https://onco.cc/biomarkers/met-amplification-readout/), [MET exon 14 skipping mutation](https://onco.cc/biomarkers/met-ex14/)
- cancers: [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/)
- drugs: [Telisotuzumab adizutecan](https://onco.cc/drugs/telisotuzumab-adizutecan/), [Telisotuzumab vedotin](https://onco.cc/drugs/telisotuzumab-vedotin/)
- terms: [Immunohistochemistry (IHC)](https://onco.cc/terms/ihc/)
- targets: [MET](https://onco.cc/targets/met/)

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JSON: https://onco.cc/api/v1/entities/met-overexpression.json