# MIB2

Source: https://onco.cc/targets/mib2/  
OnCo record `mib2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

MIB2 (E3 ubiquitin-protein ligase MIB2) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Head and neck squamous cell carcinoma.

## Summary

E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signalling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors.

IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Head and Neck Squamous Cell Carcinoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: MIB E3 ubiquitin protein ligase 2; E3 ubiquitin-protein ligase MIB2; skeletrophin; ZZZ5; FLJ39787; ZZANK1
- Tags: cancer-genes-wave
- Symbol: MIB2
- Class: tumor-suppressor
- Biology: E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signalling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Location: Cytoplasm; Endosome (UniProt). Locus 1p36.33 (HGNC).
- Where found: Head and neck squamous cell carcinoma: IntOGen driver in 1 cohort (HNSC)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:30577: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:30577
- UniProt Q96AX9: https://www.uniprot.org/uniprotkb/Q96AX9/entry
- NCBI Gene 142678: https://www.ncbi.nlm.nih.gov/gene/142678
- Ensembl ENSG00000197530: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000197530

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Head and neck squamous cell carcinoma](https://onco.cc/cancers/head-and-neck/)

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JSON: https://onco.cc/api/v1/entities/mib2.json