# Michelle Monje

Source: https://onco.cc/people/michelle-monje/  
OnCo record `michelle-monje` (Person). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Founded cancer neuroscience and led the GD2 CAR-T trial that produced the first regressions of diffuse midline glioma.

## Summary

Michelle Monje showed that neuronal activity drives glioma growth through neuroligin-3 and synaptic integration, founding the field of cancer neuroscience, and led the first-in-human trial of GD2-directed CAR T cells in H3K27M-mutant diffuse midline glioma that produced radiographic and clinical improvements in a disease with no effective therapy. She was awarded a MacArthur Fellowship and leads paediatric neuro-oncology research at Stanford.

## Fields

- Kind: Person
- Last checked: 2026-09-10
- Tags: paediatric; glioma; car-t; cancer-neuroscience
- Role: Professor of Neurology and Neurological Sciences, Stanford University; HHMI Investigator
- Specialisms: Paediatric high-grade glioma; Cancer neuroscience; GD2 CAR T cells; Diffuse midline glioma

## Sources

- Wikipedia: https://en.wikipedia.org/wiki/Michelle_Monje
- PubMed: https://pubmed.ncbi.nlm.nih.gov/?term=Monje%20M%5BAuthor%5D%20glioma%20GD2%20OR%20neuroligin

## Connected records

- technologies: [CAR-T cell therapy](https://onco.cc/technologies/car-t/)
- institutions: [Howard Hughes Medical Institute](https://onco.cc/institutions/hhmi/), [Stanford Health Care / Stanford Cancer Institute](https://onco.cc/institutions/stanford/)

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JSON: https://onco.cc/api/v1/entities/michelle-monje.json