# MIEN1

Source: https://onco.cc/targets/mien1/  
OnCo record `mien1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

MIEN1 is a small HER2-amplicon gene whose protein promotes cell migration and is strongly raised in breast and prostate cancers.

## Summary

17q12 HER2 amplicon neighbour: co-amplified and co-expressed with ERBB2 in HER2-positive breast and gastric cancer, so it appears in HER2-enriched expression signatures as a passenger of the amplification rather than a driver of its own. UniProt notes that MIEN1 is nearly absent from normal tissue outside the testis yet strongly up-regulated in breast cancer and in higher-grade prostate cancer, which makes it one of the more interesting passengers.

## Fields

- Kind: Target
- Last checked: 2026-09-24
- Also known as: migration and invasion enhancer 1; C17orf37; C35
- Tags: cansim-terms
- Symbol: MIEN1
- Class: other
- Biology: Increases cell migration by inducing filopodia at the leading edge; regulates apoptosis, possibly through CASP3; among normal tissues present only in Leydig cells, strongly up-regulated in breast cancers and higher-grade prostate adenocarcinoma at the protein level (UniProt Q9BRT3).
- Where found: Locus 17q12 (HGNC).

## Notes

- Named in the CanSim terms map 1.0.0 (docs/onco/terms.json, generated 2026-09-24), CC BY 4.0, attribution: CanSim project, an open, public-data-first cancer foundation-model programme.

## Sources

- HGNC HGNC:28230: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:28230
- UniProt Q9BRT3: https://www.uniprot.org/uniprotkb/Q9BRT3/entry

## Connected records

- targets: [HER2](https://onco.cc/targets/her2/)
- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/), [Prostate cancer](https://onco.cc/cancers/prostate/)
- terms: [Cancer AI vocabulary (CanSim terms map)](https://onco.cc/terms/cancer-ai-vocabulary/), [Co-amplification and the 17q12 HER2 amplicon](https://onco.cc/terms/co-amplification/)

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JSON: https://onco.cc/api/v1/entities/mien1.json