# MIR21

Source: https://onco.cc/targets/mir21/  
OnCo record `mir21` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

MIR21 (microRNA 21) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-small-cell lung cancer.

## Summary

UniProt has no function text for this gene; HGNC names it "microRNA 21".

CIViC holds 4 clinical evidence items and 0 assertions across 1 variant, naming Cisplatin.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: microRNA 21; hsa-mir-21; MIR-21; MIRN21
- Tags: cancer-genes-wave
- Symbol: MIR21
- Class: other
- Biology: UniProt has no function text for this gene; HGNC names it "microRNA 21". Locus 17q23.1 (HGNC).
- Where found: Non-small-cell lung cancer: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 4 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
- Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Malignant Astrocytoma; Glioma.

## Sources

- HGNC HGNC:31586: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:31586
- NCBI Gene 406991: https://www.ncbi.nlm.nih.gov/gene/406991
- Ensembl ENSG00000284190: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000284190

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/)
- pathways: [MicroRNAs in cancer](https://onco.cc/pathways/micrornas-in-cancer/)

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JSON: https://onco.cc/api/v1/entities/mir21.json