# MLF1

Source: https://onco.cc/targets/mlf1/  
OnCo record `mlf1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

MLF1 (Myeloid leukaemia factor 1) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Lung cancer.

## Summary

Involved in lineage commitment of primary haemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses COP1 activity via CSN3 which activates p53 and induces cell cycle arrest.

Open Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.49, genetic association 0.00, somatic mutation 0.97).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: myeloid leukemia factor 1; Myeloid leukemia factor 1
- Tags: cancer-genes-wave
- Symbol: MLF1
- Class: other
- Biology: Involved in lineage commitment of primary haemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus. Location: Cytoplasm; Nucleus; Cell projection, cilium; Cytoplasm, cytoskeleton, cilium basal body (UniProt). Locus 3q25.32 (HGNC).
- Where found: Lung cancer: Open Targets association 0.52 with lung cancer (MONDO_0008903)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:7125: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7125
- UniProt P58340: https://www.uniprot.org/uniprotkb/P58340/entry
- NCBI Gene 4291: https://www.ncbi.nlm.nih.gov/gene/4291
- Ensembl ENSG00000178053: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000178053

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Lung cancer (all types)](https://onco.cc/cancers/lung-cancer/)

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JSON: https://onco.cc/api/v1/entities/mlf1.json