# MLLT10

Source: https://onco.cc/targets/mllt10/  
OnCo record `mllt10` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

MLLT10 (MLLT10 histone lysine methyltransferase DOT1L cofactor) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Breast cancer, Ovarian cancer, Leukaemia and 2 more.

## Summary

Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA.

Open Targets scores its association with cancer at 0.74 (direct and indirect evidence; datatypes literature 0.87, animal model 0.47, genetic association 0.69, somatic mutation 0.98).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: MLLT10 histone lysine methyltransferase DOT1L cofactor; AF10
- Tags: cancer-genes-wave
- Symbol: MLLT10
- Class: transcription
- Biology: Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 'Lys-79' dimethylation (H3K79me2) and gene activation. Location: Nucleus (UniProt). Locus 10p12.31 (HGNC).
- Where found: Breast cancer: Open Targets association 0.64 with breast cancer (MONDO_0007254); Ovarian cancer: Open Targets association 0.57 with ovarian cancer (MONDO_0008170); Leukaemia: Open Targets association 0.57 with leukaemia (MONDO_0005059); Non-Hodgkin lymphoma: Open Targets association 0.53 with non-Hodgkin lymphoma (MONDO_0018908); Acute lymphoblastic leukaemia: Open Targets association 0.51 with acute lymphoblastic leukaemia (MONDO_0004967)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:16063: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:16063
- UniProt P55197: https://www.uniprot.org/uniprotkb/P55197/entry
- NCBI Gene 8028: https://www.ncbi.nlm.nih.gov/gene/8028
- Ensembl ENSG00000078403: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000078403

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Acute lymphoblastic leukaemia](https://onco.cc/cancers/all-leukemia/), [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/), [Leukaemia (all types)](https://onco.cc/cancers/leukaemia/), [Non-Hodgkin lymphoma (all types)](https://onco.cc/cancers/non-hodgkin-lymphoma/), [Ovarian cancer](https://onco.cc/cancers/ovarian/)

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JSON: https://onco.cc/api/v1/entities/mllt10.json