# MLPH

Source: https://onco.cc/targets/mlph/  
OnCo record `mlph` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

MLPH (Melanophilin) is a gene. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A.

Open Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.80, genetic association 0.64).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: melanophilin; Melanophilin; l1Rk3; l(1)-3Rk; Slac-2a; ln; exophilin-3; SLAC2-A
- Tags: cancer-genes-wave
- Symbol: MLPH
- Class: other
- Biology: Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A. Location: Cytoplasm (UniProt). Locus 2q37.3 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:29643: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:29643
- UniProt Q9BV36: https://www.uniprot.org/uniprotkb/Q9BV36/entry
- NCBI Gene 79083: https://www.ncbi.nlm.nih.gov/gene/79083
- Ensembl ENSG00000115648: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000115648

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/mlph.json