# MMP1

Source: https://onco.cc/targets/mmp1/  
OnCo record `mmp1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

MMP1 (Interstitial collagenase) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to HR-positive / HER2-negative breast cancer.

## Summary

Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Sacituzumab Govitecan.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: matrix metallopeptidase 1; Interstitial collagenase
- Tags: cancer-genes-wave
- Symbol: MMP1
- Class: enzyme
- Biology: Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity. Location: Secreted, extracellular space, extracellular matrix (UniProt). Locus 11q22.2 (HGNC).
- Where found: HR-positive / HER2-negative breast cancer: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:7155: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7155
- UniProt P03956: https://www.uniprot.org/uniprotkb/P03956/entry
- NCBI Gene 4312: https://www.ncbi.nlm.nih.gov/gene/4312
- Ensembl ENSG00000196611: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000196611

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [HR-positive / HER2-negative breast cancer](https://onco.cc/cancers/breast-hr-positive/)

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JSON: https://onco.cc/api/v1/entities/mmp1.json