# MMP7

Source: https://onco.cc/targets/mmp7/  
OnCo record `mmp7` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

MMP7 (Matrilysin) is an enzyme. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.

## Summary

Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase.

Open Targets scores its association with cancer at 0.57 (direct and indirect evidence; datatypes literature 0.99, animal model 0.26, genetic association 0.61, clinical 0.65).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: matrix metallopeptidase 7; Matrilysin; PUMP-1; MPSL1
- Tags: cancer-genes-wave
- Symbol: MMP7
- Class: enzyme
- Biology: Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase. Location: Secreted, extracellular space, extracellular matrix (UniProt). Locus 11q22.2 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.65. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:7174: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7174
- UniProt P09237: https://www.uniprot.org/uniprotkb/P09237/entry
- NCBI Gene 4316: https://www.ncbi.nlm.nih.gov/gene/4316
- Ensembl ENSG00000137673: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000137673

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/mmp7.json