# MMP9

Source: https://onco.cc/targets/mmp9/  
OnCo record `mmp9` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

MMP9 (Matrix metalloproteinase-9) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.

## Summary

Matrix metalloproteinase that plays an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Bevacizumab.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: matrix metallopeptidase 9; Matrix metalloproteinase-9; CLG4B
- Tags: cancer-genes-wave
- Symbol: MMP9
- Class: enzyme
- Biology: Matrix metalloproteinase that plays an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves NINJ1 to generate the Secreted ninjurin-1 form. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide. Location: Secreted, extracellular space, extracellular matrix (UniProt). Locus 20q13.12 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
- Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Inflammatory Breast Carcinoma.

## Sources

- HGNC HGNC:7176: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7176
- UniProt P14780: https://www.uniprot.org/uniprotkb/P14780/entry
- NCBI Gene 4318: https://www.ncbi.nlm.nih.gov/gene/4318
- Ensembl ENSG00000100985: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000100985

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- pathways: [The pre-metastatic niche](https://onco.cc/pathways/pre-metastatic-niche/)

---
JSON: https://onco.cc/api/v1/entities/mmp9.json