# MPEG1

Source: https://onco.cc/targets/mpeg1/  
OnCo record `mpeg1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

MPEG1 (Macrophage-expressed gene 1 protein) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.

## Summary

Pore-forming protein involved in both innate and adaptive immunity. Plays a central role in antigen cross-presentation in dendritic cells by forming a pore in antigen-containing compartments, thereby promoting delivery of antigens for cross-presentation. Also involved in innate immune response following bacterial infection; shows antibacterial activity against a wide spectrum of Gram-positive, Gram-negative and acid-fast bacteria.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: macrophage expressed 1; Macrophage-expressed gene 1 protein; P2; MPS-1; MPG1
- Tags: cancer-genes-wave
- Symbol: MPEG1
- Class: other
- Biology: Pore-forming protein involved in both innate and adaptive immunity. Plays a central role in antigen cross-presentation in dendritic cells by forming a pore in antigen-containing compartments, thereby promoting delivery of antigens for cross-presentation. Also involved in innate immune response following bacterial infection; shows antibacterial activity against a wide spectrum of Gram-positive, Gram-negative and acid-fast bacteria. Reduces the viability of the intracytosolic pathogen L.monocytogenes by inhibiting acidification of the phagocytic vacuole of host cells which restricts bacterial translocation from the vacuole to the cytosol. Required for the antibacterial activity of reactive oxygen species and nitric oxide. Pore-forming protein that plays a central role in antigen cross-presentation in dendritic cells by mediating delivery of antigens for cross-presentation. Location: Cytoplasmic vesicle membrane; Cytoplasmic vesicle, phagosome membrane; Secreted (UniProt). Locus 11q12.1 (HGNC).
- Where found: Diffuse large B-cell lymphoma: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:29619: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:29619
- UniProt Q2M385: https://www.uniprot.org/uniprotkb/Q2M385/entry
- NCBI Gene 219972: https://www.ncbi.nlm.nih.gov/gene/219972
- Ensembl ENSG00000197629: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000197629

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Diffuse large B-cell lymphoma](https://onco.cc/cancers/dlbcl/)

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JSON: https://onco.cc/api/v1/entities/mpeg1.json