# mRNA to protein concordance

Source: https://onco.cc/terms/mrna-protein-concordance/  
OnCo record `mrna-protein-concordance` (Term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

mRNA to protein concordance is how well the amount of a gene's messenger RNA tracks the amount of the protein it codes for; for many genes it tracks poorly.

## Summary

Proteogenomics combines proteomics, genomics and transcriptomics (Wikipedia); CPTAC applied it to TCGA-linked tumours and measured, gene by gene, how well transcript levels predict protein levels. Correlations are strong for some genes and near zero or negative for others because of post-transcriptional and post-translational regulation and protein complex stoichiometry, so an expression model is not a protein model, and phosphorylation-driven pathway activity is invisible to RNA.

## Fields

- Kind: Term
- Last checked: 2026-09-24
- Also known as: mRNA-protein concordance; mRNA protein concordance; transcript-protein correlation; mRNA-protein correlation; proteogenomic concordance
- Tags: cansim-terms

## Notes

- Listed in the CanSim terms map 1.0.0 (docs/onco/terms.json, generated 2026-09-24), CC BY 4.0, attribution: CanSim project, an open, public-data-first cancer foundation-model programme; CanSim page path /terms/mrna-protein-concordance.

## Sources

- Wikipedia: https://en.wikipedia.org/wiki/Proteogenomics
- Wikipedia: https://en.wikipedia.org/wiki/Proteogenomics

## Connected records

- collections: [CPTAC (Clinical Proteomic Tumor Analysis Consortium)](https://onco.cc/collections/cptac/)
- terms: [Cancer AI vocabulary (CanSim terms map)](https://onco.cc/terms/cancer-ai-vocabulary/), [Deep mass-spectrometry proteome (CPTAC)](https://onco.cc/terms/mass-spec-proteome/), [Pathway activation state (phosphosignalling)](https://onco.cc/terms/pathway-activation-state/), [Post-transcriptional and post-translational regulation](https://onco.cc/terms/post-transcriptional-regulation-term/), [Spearman rank correlation](https://onco.cc/terms/spearman-correlation/)
- technologies: [Proteomics & phosphoproteomics](https://onco.cc/technologies/proteomics/)
- targets: [DCLK1](https://onco.cc/targets/dclk1/), [DNAJC12](https://onco.cc/targets/dnajc12/), [E2F7](https://onco.cc/targets/e2f7/), [PHLPP2](https://onco.cc/targets/phlpp2/)

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JSON: https://onco.cc/api/v1/entities/mrna-protein-concordance.json