# MSR1

Source: https://onco.cc/targets/msr1/  
OnCo record `msr1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

MSR1 (Macrophage scavenger receptor types I and II) is a gene. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Membrane receptor that mediates the binding, endocytosis and phagocytosis of a broad range of ligands. Recognises and internalises modified forms of low-density lipoproteins including acetylated LDL (AcLDL) and oxidised LDL (OxLDL), thereby promoting cholesterol uptake and contributing to foam cell formation during atherogenesis. Binds various pathogen-associated and damage-associated molecules, including bacterial cell wall components, apoptotic cell debris and polyanionic ligands, supporting macrophage clearance activity in innate immune defense.

Open Targets scores its association with cancer at 0.58 (direct and indirect evidence; datatypes literature 0.97, genetic association 0.73, genetic literature 0.30).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: macrophage scavenger receptor 1; Macrophage scavenger receptor types I and II; SCARA1; CD204; SR-AI; SR-AII; SR-AIII; SR-A
- Tags: cancer-genes-wave
- Symbol: MSR1
- Class: other
- Biology: Membrane receptor that mediates the binding, endocytosis and phagocytosis of a broad range of ligands. Recognises and internalises modified forms of low-density lipoproteins including acetylated LDL (AcLDL) and oxidised LDL (OxLDL), thereby promoting cholesterol uptake and contributing to foam cell formation during atherogenesis. Binds various pathogen-associated and damage-associated molecules, including bacterial cell wall components, apoptotic cell debris and polyanionic ligands, supporting macrophage clearance activity in innate immune defense. Upon stimulation by CpG DNA, mediates activation of LYN, which phosphorylates SYK that is subsequently recruited to endosomal TLR9 to promote downstream TLR9 signalling. Does not internalise acetylated LDL. Location: Cell membrane (UniProt). Locus 8p22 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:7376: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7376
- UniProt P21757: https://www.uniprot.org/uniprotkb/P21757/entry
- NCBI Gene 4481: https://www.ncbi.nlm.nih.gov/gene/4481
- Ensembl ENSG00000038945: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000038945

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

---
JSON: https://onco.cc/api/v1/entities/msr1.json