# MT-125

Source: https://onco.cc/drugs/mt-125/  
OnCo record `mt-125` (Treatment). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

MT-125 is an experimental small molecule from Myosin Therapeutics, in phase 1 trials for glioblastoma, acute myeloid leukaemia and pancreatic adenocarcinoma.

## Summary

MT-125 is a small molecule (oral, brain-penetrant) from Myosin Therapeutics, with Mayo Clinic as partner. A brain-penetrant dual inhibitor of non-muscle myosin IIA and IIB (the products of MYH9 and MYH10). The company says it is believed to prevent tumour invasion and proliferation while activating the tumour cell's own stress responses; in preclinical studies it increased the effect of radiation. Its furthest stage is phase 1, for glioblastoma, acute myeloid leukaemia and pancreatic adenocarcinoma. ClinicalTrials.gov registers it in 2 studies linked below. Phase 1/2 STAR-GBM (NCT07185880) recruiting; second phase 1/2 study NCT07604285 not yet recruiting (registry, 3 Nov 2026). Whether it works in people has not been established unless a trial below reports it.

## Fields

- Kind: Treatment
- Status: phase-1
- Last checked: 2026-11-03
- Tags: pipeline; ctgov-ingest
- Code: MT-125
- Modality: Small molecule (oral, brain-penetrant)
- Mechanism: A brain-penetrant dual inhibitor of non-muscle myosin IIA and IIB (the products of MYH9 and MYH10). The company says it is believed to prevent tumour invasion and proliferation while activating the tumour cell's own stress responses; in preclinical studies it increased the effect of radiation.

## Sources

- Myosin Therapeutics: myosintherapeutics.com: https://www.myosintherapeutics.com/pipeline.php
- Myosin Therapeutics: myosintherapeutics.com: https://www.myosintherapeutics.com/pipeline.php
- Myosin Therapeutics: myosintherapeutics.com: https://www.myosintherapeutics.com/pipeline.php
- Myosin Therapeutics: clinicaltrials.gov: https://clinicaltrials.gov/api/v2/studies/NCT07604285
- ClinicalTrials.gov: trials of MT-125: https://clinicaltrials.gov/search?intr=MT-125

## Connected records

- cancers: [Glioma & glioblastoma](https://onco.cc/cancers/glioblastoma/)
- targets: [MYH9](https://onco.cc/targets/myh9/)
- companies: [Myosin Therapeutics](https://onco.cc/companies/myosin-therapeutics/)
- trials: [A Phase 1/2 Study of Safety and Tolerability of MT-125 With Chemoradiation in Patients With Newly Diagnosed MGMT Methylated Glioblastoma](https://onco.cc/trials/nct07604285/), [A Phase 1/2 Study of the Safety and Tolerability of MT-125 in GBM Patients](https://onco.cc/trials/nct07185880/)

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JSON: https://onco.cc/api/v1/entities/mt-125.json