# MT-ND6

Source: https://onco.cc/targets/mt-nd6/  
OnCo record `mt-nd6` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

MT-ND6 (NADH-ubiquinone oxidoreductase chain 6) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.

## Summary

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyses electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.

Open Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes clinical 0.67, literature 0.29, genetic association 0.63, somatic mutation 0.18, animal model 0.33).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6; NADH-ubiquinone oxidoreductase chain 6; NAD6; ND6; MTND6
- Tags: cancer-genes-wave
- Symbol: MT-ND6
- Class: other
- Biology: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyses electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I. Location: Mitochondrion inner membrane (UniProt). Locus mitochondria (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.67. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:7462: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7462
- UniProt P03923: https://www.uniprot.org/uniprotkb/P03923/entry
- NCBI Gene 4541: https://www.ncbi.nlm.nih.gov/gene/4541
- Ensembl ENSG00000198695: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000198695

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/mt-nd6.json