# MTCP1

Source: https://onco.cc/targets/mtcp1/  
OnCo record `mtcp1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

MTCP1 (Protein p13 MTCP-1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer.

## Summary

Enhances the phosphorylation and activation of AKT1 and AKT2.

Open Targets scores its association with cancer at 0.60 (direct and indirect evidence; datatypes literature 0.53, genetic association 0.00, somatic mutation 0.96).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: mature T cell proliferation 1; Protein p13 MTCP-1; P13MTCP1; p8MTCP1; TCL1C
- Tags: cancer-genes-wave
- Symbol: MTCP1
- Class: other
- Biology: Enhances the phosphorylation and activation of AKT1 and AKT2. Locus Xq28 (HGNC).
- Where found: Breast cancer: Open Targets association 0.54 with breast cancer (MONDO_0007254)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:7423: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7423
- UniProt P56278: https://www.uniprot.org/uniprotkb/P56278/entry
- NCBI Gene 4515: https://www.ncbi.nlm.nih.gov/gene/4515
- Ensembl ENSG00000214827: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000214827

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/)

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JSON: https://onco.cc/api/v1/entities/mtcp1.json