# MUTYH

Source: https://onco.cc/targets/mutyh/  
OnCo record `mutyh` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

MUTYH (Adenine DNA glycosylase) is an enzyme. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. Tied to Colorectal cancer, Gastric & gastro-oesophageal junction cancer, Breast cancer and 5 more.

## Summary

Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2-OH-A DNA glycosylase activities.

Open Targets scores its association with cancer at 0.86 (direct and indirect evidence; datatypes genetic literature 0.66, affected pathway 0.87, literature 0.85, genetic association 0.81, somatic mutation 0.91).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: mutY DNA glycosylase; Adenine DNA glycosylase
- Tags: cancer-genes-wave
- Symbol: MUTYH
- Class: enzyme
- Biology: Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2-OH-A DNA glycosylase activities. Location: Nucleus; Mitochondrion (UniProt). Locus 1p34.1 (HGNC).
- Where found: Colorectal cancer: Open Targets association 0.78 with colorectal cancer (MONDO_0005575); Gastric & gastro-oesophageal junction cancer: Open Targets association 0.72 with gastric cancer (MONDO_0001056); Breast cancer: Open Targets association 0.64 with breast cancer (MONDO_0007254); Ovarian cancer: Open Targets association 0.57 with ovarian cancer (MONDO_0008170); Skin cancer: Open Targets association 0.55 with skin cancer (MONDO_0002898); Lung cancer: Open Targets association 0.52 with lung cancer (MONDO_0008903)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt keyword "DNA repair". Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:7527: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7527
- UniProt Q9UIF7: https://www.uniprot.org/uniprotkb/Q9UIF7/entry
- NCBI Gene 4595: https://www.ncbi.nlm.nih.gov/gene/4595
- Ensembl ENSG00000132781: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000132781

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Brain and spinal cord tumours (all types)](https://onco.cc/cancers/brain-tumours/), [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/), [Colorectal cancer](https://onco.cc/cancers/colorectal/), [Endometrial cancer](https://onco.cc/cancers/endometrial/), [Gastric & gastro-oesophageal junction cancer](https://onco.cc/cancers/gastric/), [Lung cancer (all types)](https://onco.cc/cancers/lung-cancer/), [Ovarian cancer](https://onco.cc/cancers/ovarian/), [Skin cancer (all types)](https://onco.cc/cancers/skin-cancer/)

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JSON: https://onco.cc/api/v1/entities/mutyh.json