# MX2

Source: https://onco.cc/targets/mx2/  
OnCo record `mx2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

MX2 (Interferon-induced GTP-binding protein Mx2) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer and Melanoma.

## Summary

Interferon-induced dynamin-like GTPase with potent antiviral activity against human immunodeficiency virus type 1 (HIV-1). Acts by targeting the viral capsid and affects the nuclear uptake and/or stability of the HIV-1 replication complex and the subsequent chromosomal integration of the proviral DNA. Exhibits antiviral activity also against simian immunodeficiency virus (SIV-mnd).

Open Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.49, animal model 0.41, genetic association 0.66).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: MX dynamin like GTPase 2; Interferon-induced GTP-binding protein Mx2
- Tags: cancer-genes-wave
- Symbol: MX2
- Class: other
- Biology: Interferon-induced dynamin-like GTPase with potent antiviral activity against human immunodeficiency virus type 1 (HIV-1). Acts by targeting the viral capsid and affects the nuclear uptake and/or stability of the HIV-1 replication complex and the subsequent chromosomal integration of the proviral DNA. Exhibits antiviral activity also against simian immunodeficiency virus (SIV-mnd). May play a role in regulating nucleocytoplasmic transport and cell-cycle progression. Location: Cytoplasm; Nucleus; Nucleus, nuclear pore complex (UniProt). Locus 21q22.3 (HGNC).
- Where found: Skin cancer: Open Targets association 0.50 with skin cancer (MONDO_0002898); Melanoma: Open Targets association 0.54 with melanoma (MONDO_0005105)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:7533: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7533
- UniProt P20592: https://www.uniprot.org/uniprotkb/P20592/entry
- NCBI Gene 4600: https://www.ncbi.nlm.nih.gov/gene/4600
- Ensembl ENSG00000183486: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000183486

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Melanoma](https://onco.cc/cancers/melanoma/), [Skin cancer (all types)](https://onco.cc/cancers/skin-cancer/)

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JSON: https://onco.cc/api/v1/entities/mx2.json