# MXI1

Source: https://onco.cc/targets/mxi1/  
OnCo record `mxi1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

MXI1 (Max-interacting protein 1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.

## Summary

Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognises the core sequence 5'-CAC[GA]TG-3'. MXI1 thus antagonises MYC transcriptional activity by competing for MAX.

Open Targets scores its association with cancer at 0.64 (direct and indirect evidence; datatypes literature 0.94, genetic association 0.76, genetic literature 0.61).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: MAX interactor 1, dimerization protein; Max-interacting protein 1; MXD2; MAD2; bHLHc11
- Tags: cancer-genes-wave
- Symbol: MXI1
- Class: transcription
- Biology: Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognises the core sequence 5'-CAC[GA]TG-3'. MXI1 thus antagonises MYC transcriptional activity by competing for MAX. Location: Nucleus (UniProt). Locus 10q25.2 (HGNC).
- Where found: Prostate cancer: Open Targets association 0.59 with prostate cancer (MONDO_0008315)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:7534: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7534
- UniProt P50539: https://www.uniprot.org/uniprotkb/P50539/entry
- NCBI Gene 4601: https://www.ncbi.nlm.nih.gov/gene/4601
- Ensembl ENSG00000119950: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000119950

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Prostate cancer](https://onco.cc/cancers/prostate/)
- pathways: [Mitosis & the spindle assembly checkpoint](https://onco.cc/pathways/mitotic-spindle-checkpoint/)

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JSON: https://onco.cc/api/v1/entities/mxi1.json