# MYB

Source: https://onco.cc/targets/myb/  
OnCo record `myb` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

MYB (Transcriptional activator Myb) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Skin cancer, Breast cancer, Colorectal cancer and 5 more.

## Summary

Transcriptional activator; DNA-binding protein that specifically recognise the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of haematopoietic progenitor cells.

CIViC holds 7 clinical evidence items and 2 assertions across 3 variants. Open Targets scores its association with cancer at 0.69 (direct and indirect evidence; datatypes affected pathway 0.44, literature 0.99, genetic association 0.10, somatic mutation 0.98, animal model 0.71).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: MYB proto-oncogene, transcription factor; Transcriptional activator Myb; c-myb
- Tags: cancer-genes-wave
- Symbol: MYB
- Class: transcription
- Biology: Transcriptional activator; DNA-binding protein that specifically recognise the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of haematopoietic progenitor cells. Location: Nucleus (UniProt). Locus 6q23.3 (HGNC).
- Where found: Skin cancer: Open Targets association 0.58 with skin cancer (MONDO_0002898); Breast cancer: Open Targets association 0.56 with breast cancer (MONDO_0007254); Colorectal cancer: Open Targets association 0.55 with colorectal cancer (MONDO_0005575); Leukaemia: Open Targets association 0.52 with leukaemia (MONDO_0005059); Non-Hodgkin lymphoma: Open Targets association 0.52 with non-Hodgkin lymphoma (MONDO_0018908); Paediatric low-grade glioma: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 7 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
- Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Diffuse Astrocytoma, MYB- Or MYBL1-altered; Angiocentric Glioma; Isomorphic Diffuse Glioma.

## Sources

- HGNC HGNC:7545: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7545
- UniProt P10242: https://www.uniprot.org/uniprotkb/P10242/entry
- NCBI Gene 4602: https://www.ncbi.nlm.nih.gov/gene/4602
- Ensembl ENSG00000118513: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000118513

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/), [Colorectal cancer](https://onco.cc/cancers/colorectal/), [Leukaemia (all types)](https://onco.cc/cancers/leukaemia/), [Melanoma](https://onco.cc/cancers/melanoma/), [Non-Hodgkin lymphoma (all types)](https://onco.cc/cancers/non-hodgkin-lymphoma/), [Oral cavity cancer (mouth and tongue)](https://onco.cc/cancers/oral-cavity-cancer/), [Paediatric low-grade glioma](https://onco.cc/cancers/paediatric-low-grade-glioma/), [Skin cancer (all types)](https://onco.cc/cancers/skin-cancer/)

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JSON: https://onco.cc/api/v1/entities/myb.json