# MYCL

Source: https://onco.cc/targets/mycl/  
OnCo record `mycl` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

MYCL (MYCL proto-oncogene, bHLH transcription factor) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Multiple myeloma, Skin cancer and Melanoma.

## Summary

UniProt has no function text for P12524; HGNC names it "MYCL proto-oncogene, bHLH transcription factor".

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming JQ1 and I-BET151. Open Targets scores its association with cancer at 0.65 (direct and indirect evidence; datatypes literature 0.94, affected pathway 0.35, genetic association 0.00, somatic mutation 0.96).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: MYCL proto-oncogene, bHLH transcription factor; bHLHe38; MYCL1
- Tags: cancer-genes-wave
- Symbol: MYCL
- Class: other
- Biology: UniProt has no function text for P12524; HGNC names it "MYCL proto-oncogene, bHLH transcription factor". Location: Nucleus (UniProt). Locus 1p34.2 (HGNC).
- Where found: Multiple myeloma: CIViC evidence names this disease; Skin cancer: Open Targets association 0.56 with skin cancer (MONDO_0002898); Melanoma: Open Targets association 0.55 with melanoma (MONDO_0005105)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 2 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:7555: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7555
- UniProt P12524: https://www.uniprot.org/uniprotkb/P12524/entry
- NCBI Gene 4610: https://www.ncbi.nlm.nih.gov/gene/4610
- Ensembl ENSG00000116990: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000116990

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Melanoma](https://onco.cc/cancers/melanoma/), [Multiple myeloma](https://onco.cc/cancers/multiple-myeloma/), [Skin cancer (all types)](https://onco.cc/cancers/skin-cancer/)

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JSON: https://onco.cc/api/v1/entities/mycl.json