# MYH11

Source: https://onco.cc/targets/myh11/  
OnCo record `myh11` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

MYH11 (Myosin-11) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver, a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer, Breast cancer, Head and neck squamous cell carcinoma and 5 more.

## Summary

Muscle contraction.

IntOGen calls it a driver in 10 cohorts (5 activating, 5 loss-of-function), covering Acute Myeloid Leukaemia, Invasive Breast Carcinoma, Cholangiocarcinoma, Head and Neck Squamous Cell Carcinoma, Low-Grade Glioma, NOS, Melanoma and others.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: myosin heavy chain 11; Myosin-11; SMMHC; SMMS-1
- Tags: cancer-genes-wave
- Symbol: MYH11
- Class: tumor-suppressor
- Biology: Muscle contraction. Location: Melanosome (UniProt). Locus 16p13.11 (HGNC).
- Where found: Prostate cancer: IntOGen driver in 2 cohorts (PRAD, PROSTATE); Breast cancer: IntOGen driver in 1 cohort (BRCA); Head and neck squamous cell carcinoma: IntOGen driver in 1 cohort (HNSC); Nasopharyngeal carcinoma: IntOGen driver in 1 cohort (NPC); Sarcomas: IntOGen driver in 1 cohort (SOFT_TISSUE); Acute myeloid leukaemia: IntOGen driver in 1 cohort (AML)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 5 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 5 cohorts; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
- Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Low-Grade Glioma, NOS.

## Sources

- HGNC HGNC:7569: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7569
- UniProt P35749: https://www.uniprot.org/uniprotkb/P35749/entry
- NCBI Gene 4629: https://www.ncbi.nlm.nih.gov/gene/4629
- Ensembl ENSG00000133392: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000133392

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Acute myeloid leukaemia](https://onco.cc/cancers/aml/), [Biliary tract cancer (cholangiocarcinoma)](https://onco.cc/cancers/cholangiocarcinoma/), [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/), [Head and neck squamous cell carcinoma](https://onco.cc/cancers/head-and-neck/), [Melanoma](https://onco.cc/cancers/melanoma/), [Nasopharyngeal carcinoma](https://onco.cc/cancers/nasopharyngeal/), [Prostate cancer](https://onco.cc/cancers/prostate/), [Sarcomas (soft tissue, bone, GIST)](https://onco.cc/cancers/sarcoma/)

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JSON: https://onco.cc/api/v1/entities/myh11.json